Thesis / Dissertation

Profiling the molecular mechanisms underlying negative cross-resistance to insecticides using Drosophila melanogaster

Mohamad Fakhrur Razi Ghazali, Trent Perry (ed.)

Published : 2020

Abstract

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate neurotransmission at cholinergic synapses. The nAChRs are mainly expressed in the central nervous system and are highly conserved across a wide range of insect species. Neonicotinoids and spinosyns are two classes of insecticide that target nAChR subunits to kill pest insects. Mutations in genes encoding several nAChR subunits in various insect species, as well as in Drosophila melanogaster, have been documented as conferring insecticide resistance. Chemical control including insecticides has been a key tool in controlling pest insects. The cycle of insecticide use, resistance evolution and insecticide rep..

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