Thesis / Dissertation

Investigating the role of macrophages in gastric cancer

Yu-Kuan Huang, Alex Boussioutas (ed.)

Published : 2020

Abstract

Gastric cancer (GC) is lethal, with standard treatments offering little benefit. The immune component of the tumour microenvironment has been shown to highly influence GC progression and response to immune checkpoint therapies (ICTs). Tumour-associated macrophages (TAMs), one of the most abundant immune infiltrates in GC, are known for their plasticity and multiplicity of function. An abundance of TAMs is commonly associated with poor survival of cancer patients. However, their influences on survival in the GC setting are inconsistent between studies possibly due to a range of activation states and phenotypes and require further investigation. In this study, a human GC cohort was interrogate..

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