Thesis / Dissertation

Assessing the Efficacy of Bisdipyrrins as Ligands for in Vivo Applications in Disease

Jacob Alexander Rowan, Paul Donnelly (ed.)

Published : 2020

Abstract

Porphyrins are tetrapyrrolic macrocycles which form highly stable metal complexes crucial to many biological processes. These complexes are characterised by a high kinetic barrier to decomplexation, which is a desirable quality in the design of new radiopharmaceuticals. Positron Emission Tomography (PET) imaging makes use of radionuclides such as copper-64 (half life of 12.7 hours) to aid in the diagnosis of disease. Current reports of porphyrin ligands radiolabelled with copper-64 are limited, due to the typically forcing conditions required to achieve sufficient radiolabelling for application. 2,2’-Bisdipyrrins are acyclic tetrapyrroles that form charge-neutral square-planar complexes with..

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University of Melbourne Researchers