Thesis / Dissertation

Volumetric Measures of the Medial Temporal Structures and their Neuropsychological Correlates in Alzheimer’s Disease

Yi Leng Fung, Stephen Bowden (ed.)

Published : 2020

Abstract

Diagnosing Alzheimer’s disease (AD) in its earliest phases is difficult. A combination of standardised cognitive testing with AD-related biomarkers such as medial temporal atrophy observed on neuroimaging scans has been proposed to improve the diagnostic process of AD detection. The availability of automated volumetric segmentation software presents as a promising avenue for the incorporation of quantitative volumetric measures into routine clinical workup. However, the performance of these automated protocols in a clinical context remains to be clarified. This thesis aimed to examine the use of automated segmentation in a “real-world” clinical setting against the gold standard of manual seg..

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