Identification of molecular phenotypes and their regulation in cancer

Abstract

Complex diseases manifest through the dysregulation of otherwise finely regulated transcriptional programs resulting in functional alterations. Insight into altered transcriptional processes and their subsequent functional consequences allow molecular characterisation of disease phenotypes and can lead to the identification of potential therapeutic targets. The altered regulation of transcriptional programs can be identified using computational and statistical methods to infer gene regulatory networks that are changed between biological contexts. Numerous methods have been developed to infer conditional relationships however extensive evaluations remain scarce because of a lack of validation..