The role of neutrophils in immune responses in malaria infection

Abstract

Abstract Malaria remains a major health challenge worldwide with an estimated incidence of more than 200 million cases per year, and is one of the leading causes of morbidity and mortality in tropical and subtropical regions. Plasmodium falciparum malaria causes severe morbidity and mortality, especially in young children and pregnant women. Clinical malaria is caused by blood-stage parasites. The mature stage of P. falciparum parasites produces the clonally variant adhesion protein called P. falciparum erythrocyte membrane protein 1 (PfEMP1) which is expressed on the surface of infected erythrocytes (IE) and mediates attachment to endothelial surface receptors. If malaria is caused during..