Journal article

Validation of an Automated Quantification of Relative Ellipsoid Zone Reflectivity on Spectral Domain-Optical Coherence Tomography Images

Sarah Thiele, Ben Isselmann, Maximilian Pfau, Frank G Holz, Steffen Schmitz-Valckenberg, Zhichao Wu, Robyn H Guymer, Chi D Luu

Translational Vision Science and Technology | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2020

Abstract

Purpose: Relative ellipsoid zone reflectivity (rEZR) represents a potential biomarker of photoreceptor health on spectral-domain optical coherence tomography (SD-OCT). Because manual quantification of rEZR is laborious and lacks of spatial resolution, automated quantification of the rEZR would be beneficial. The purpose of this study was to evaluate the reliability and reproducibility of an automated rEZR quantification method. Methods: The rEZR was acquired using a manual and an automated approach in eyes with age-related macular degeneration (AMD) and healthy controls. The rEZR obtained from both methods was compared and the agreement between the methods and their reproducibility assessed...

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Grants

Awarded by National Health & Medical Research Council of Australia


Awarded by BONFOR GEROK Program, Faculty of Medicine, University of Bonn


Funding Acknowledgements

Supported by the National Health & Medical Research Council of Australia (Project Grant no.: APP1027624 [RHG, CDL]; and fellowship grant nos.: GNT1103013 [RHG], Bupa Health Foundation, Australia (RHG, CDL), BONFOR GEROK Program, Faculty of Medicine, University of Bonn, Grant No O-137.0026 to ST; by the Maria-von-Linden Program, University of Bonn to ST; by the Werner Jackstadt Nachwuchspreis of the German Retina Society to ST and by the BM-AXIS program of the University of Bonn and University of Melbourne to ST. The Centre for Eye Research Australia receives operational infrastructure support from the Victorian Government.