Journal article

Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-beta-negative cognitively normal individuals

Colin Groot, Vincent Dore, Joanne Robertson, Samantha C Burnham, Greg Savage, Rik Ossenkoppele, Christopher C Rowe, Victor L Villemagne

NEUROBIOLOGY OF AGING | ELSEVIER SCIENCE INC | Published : 2021

Abstract

We examined whether mesial temporal (Me) tau relates to cognitive performance in 47 amyloid-β (Aβ)-negative, cognitively normal older adults (>60 years old). Me-tau was measured using [18F]flortaucipir-positron emission tomography standardized uptake value ratio. The effect of continuous and categorical (stratified at standardized uptake value ratio = 1.2 [21% Me-positive]) Me-tau on cognition (mini-mental state examination, pre-Alzheimer's cognitive composite, a memory composite, and a nonmemory composite score) was examined using general linear models, and associations between Me-tau and [18F]flortaucipir signal in the neocortex were assessed using voxelwise regressions (continuous) and vo..

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Grants

Awarded by Alzheimer Nederland


Awarded by National Institute on Aging of the National Institutes of Health within the Department of Health and Human Services in the United States of America


Funding Acknowledgements

The study received a research fellowship grant from Alzheimer Nederland (WE.15-2018-02, CG), and research support from the National Health and Medical Research Council (NHMRC), Avid Radiopharmaceuticals (Eli Lilly) and the National Institute on Aging of the National Institutes of Health within the Department of Health and Human Services in the United States of America (R01 AG029672, RO). The funding sources did not have any involvement or influence in study design, data production, data analysis, decision to publish, or preparation of the manuscript.