A review of T helper 17 cell-related cytokines in serum and saliva in periodontitis
Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson
Cytokine | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2021
Periodontitis is a chronic inflammatory disease with a complex underlying immunopathology. Cytokines, as molecular mediators of inflammation, play a role in all stages of disease progression. T helper 17 (Th17) cells are thought to play a role in periodontitis. Th17 cell development and maintenance requires a pro-inflammatory cytokine milieu, with many of the cytokines implicated in the pathogenesis of periodontitis. Serum and saliva are easily accessible biofluids which can represent the systemic and local environment to promote the development of Th17 cells. Here we review human clinical studies that investigate IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, I..View full abstract
Awarded by Australian National Health and Medical Research Council
This study was supported by a grant from the Australian National Health and Medical Research Council (APP1029878).