Journal article

Fatal and Nonfatal Events Within 14 days After Early, Intensive Mobilization Poststroke

Julie Bernhardt, Karen Borschmann, Janice M Collier, Amanda G Thrift, Peter Langhorne, Sandy Middleton, Richard I Lindley, Helen M Dewey, Philip Bath, Catherine M Said, Leonid Churilov, Fiona Ellery, Christopher Bladin, Christopher M Reid, Judith H Frayne, Velandai Srikanth, Stephen J Read, Geoffrey A Donnan

NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021

Abstract

OBJECTIVE: This tertiary analysis from AVERT examined fatal and non-fatal Serious Adverse Events (SAEs) at 14 days. METHOD: AVERT was a prospective, parallel group, assessor blinded, randomized international clinical trial comparing mobility training commenced 80 years subgroups, but there was no significant treatment by subgroup interaction. No difference in non-fatal SAEs found. CONCLUSION: While the overall case fatality at 14 days post-stroke was only 3.8%, mortality adjusted for age and stroke severity was increased with high dose, intensive training compared to usual care. Stroke progression was more common in VEM. CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that v..

View full abstract

Grants

Awarded by National Health and Medical Council Australia


Awarded by Chest Heart and Stroke Scotland


Awarded by Northern Ireland Chest Heart and Stroke, Singapore Health


Awarded by UK Stroke Association


Awarded by UK National Institute Health Research (Health Technology Assessment Project)


Awarded by Australian Research Council


Funding Acknowledgements

Supported by National Health and Medical Council Australia (386201, 1041401), Chest Heart and Stroke Scotland (Res08/A114), Northern Ireland Chest Heart and Stroke, Singapore Health (SHF/FG401P/2008), UK Stroke Association (TSA2009/09), UK National Institute Health Research (Health Technology Assessment Project 12/01/16), and Australian Research Council (0991086).