Journal article

Seeking an optimal dosing regimen for OZ439-DSM265 combination therapy for treating uncomplicated falciparum malaria

Saber Dini, Sophie G Zaloumis, David J Price, Nathalie Gobeau, Anne Kümmel, Mohammed Cherkaoui, Joerg J Moehrle, James S McCarthy, Julie A Simpson

Cold Spring Harbor Laboratory

Abstract

AbstractThe efficacy of Artemisinin-based Combination Therapies (ACTs), the first- line treatments of uncomplicated falciparum malaria, has been declining in malaria endemic countries due to the emergence of malaria parasites resistant to these com- pounds. Novel alternative therapies are needed urgently to prevent the likely surge in morbidity and mortality due to failing ACTs. This study investigates the efficacy of the combination of two novel drugs, OZ439 and DSM265, using a biologically informed within-host mathematical model that accounts for the pharmacodynamic interaction between the two drugs. Model parameters were estimated using data from healthy volunteers infected with falciparu..

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