Journal article

Cp1/cathepsin L is required for autolysosomal clearance in Drosophila

Tianqi Xu, Shannon Nicolson, Jarrod J Sandow, Sonia Dayan, Xin Jiang, Jantina A Manning, Andrew Webb, Sharad Kumar, Donna Denton



Macroautophagy/autophagy is a highly conserved lysosomal degradative pathway important for maintaining cellular homeostasis. Much of our current knowledge of autophagy is focused on the initiation steps in this process. Recently, an understanding of later steps, particularly lysosomal fusion leading to autolysosome formation and the subsequent role of lysosomal enzymes in degradation and recycling, is becoming evident. Autophagy can function in both cell survival and cell death, however, the mechanisms that distinguish adaptive/survival autophagy from autophagy-dependent cell death remain to be established. Here, using proteomic analysis of Drosophila larval midguts during degradation, we id..

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Awarded by Australian Research Council

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the Australian Research Council [DP170100623]; National Health and Medical Research Council [1103006]; National Health and Medical Research Council [1124490].