Journal article

Establishing operant conflict tests for the translational study of anxiety in mice

Sara Oberrauch, Hannes Sigrist, Eva Sautter, Samuel Gerster, Dominik R Bach, Christopher R Pryce

Psychopharmacology | SPRINGER | Published : 2019

Abstract

RATIONALE: In conflict-based anxiety tests, rodents decide between actions with simultaneous rewarding and aversive outcomes. In humans, computerised operant conflict tests have identified response choice, latency, and vigour as distinct behavioural components. Animal operant conflict tests for measurement of these components would facilitate translational study. OBJECTIVES: In C57BL/6 mice, two operant conflict tests for measurement of response choice, latency, and vigour were established, and effects of chlordiazepoxide (CDZ) thereon investigated. METHODS: Mice were moderately diet-restricted to increase sucrose reward salience. A 1-lever test required responding under medium-effort reward..

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