Establishing operant conflict tests for the translational study of anxiety in mice
Sara Oberrauch, Hannes Sigrist, Eva Sautter, Samuel Gerster, Dominik R Bach, Christopher R Pryce
Psychopharmacology | SPRINGER | Published : 2019
RATIONALE: In conflict-based anxiety tests, rodents decide between actions with simultaneous rewarding and aversive outcomes. In humans, computerised operant conflict tests have identified response choice, latency, and vigour as distinct behavioural components. Animal operant conflict tests for measurement of these components would facilitate translational study. OBJECTIVES: In C57BL/6 mice, two operant conflict tests for measurement of response choice, latency, and vigour were established, and effects of chlordiazepoxide (CDZ) thereon investigated. METHODS: Mice were moderately diet-restricted to increase sucrose reward salience. A 1-lever test required responding under medium-effort reward..View full abstract
Awarded by Swiss National Science Foundation
This research was funded by the Swiss National Science Foundation (grant 31003A-160147 to CRP).