Journal article

Global genomic epidemiology of Streptococcus pyogenes

Magnus G Jespersen, Jake A Lacey, Steven YC Tong, Mark R Davies

Infection Genetics and Evolution | ELSEVIER | Published : 2020

Abstract

Streptococcus pyogenes is one of the Top 10 human infectious disease killers worldwide causing a range of clinical manifestations in humans. Colonizing a range of ecological niches within its sole host, the human, is key to the ability of this opportunistic pathogen to cause direct and post-infectious manifestations. The expansion of genome sequencing capabilities and data availability over the last decade has led to an improved understanding of the evolutionary dynamics of this pathogen within a global framework where epidemiological relationships and evolutionary mechanisms may not be universal. This review uses the recent publication by Davies et al., 2019 as an updated global framework t..

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Grants

Awarded by National Health and Medical Research Council of Australia Career Development Fellowship


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

MGJ is supported by The Melbourne Research Scholarship from The University of Melbourne. MRD is supported by a University of Melbourne CR Roper Fellowship. SYCT is supported by a National Health and Medical Research Council of Australia Career Development Fellowship (#1145033). We acknowledge the essential work of S. pyogenes typing databases curators hosted by the CDC and pubmlst. We thank Dr Rebecca Chisholm for insight into data plotting. Our work on S. pyogenes global population genomics is supported by the Wellcome Trust UK and the National Health and Medical Research Council of Australia (project grants 1130455 and 1098319). We would also like to thank the S. pyogenes community and public health laboratories for contributing to publicly available sequence data repositories.