Transcriptional Memory-Like Imprints and Enhanced Functional Activity in gamma delta T Cells Following Resolution of Malaria Infection
Rasika Kumarasingha, Lisa J Ioannidis, Waruni Abeysekera, Stephanie Studniberg, Dinidu Wijesurendra, Ramin Mazhari, Daniel P Poole, Ivo Mueller, Louis Schofield, Diana S Hansen, Emily M Eriksson
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2020
γδ T cells play an essential role in the immune response to many pathogens, including Plasmodium. However, long-lasting effects of infection on the γδ T cell population still remain inadequately understood. This study focused on assessing molecular and functional changes that persist in the γδ T cell population following resolution of malaria infection. We investigated transcriptional changes and memory-like functional capacity of malaria pre-exposed γδ T cells using a Plasmodium chabaudi infection model. We show that multiple genes associated with effector function (chemokines, cytokines and cytotoxicity) and antigen-presentation were upregulated in P. chabaudi-exposed γδ T cells compared t..View full abstract
Awarded by NHMRC
Awarded by NHMRC Senior Research Fellowship
This work was supported by NHMRC grant APP106722 (EE). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. IM is supported by an NHMRC Senior Research Fellowship (#1043345). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.