Glycosylated Nanoparticles Derived from RAFT Polymerization for Effective Drug Delivery to Macrophages
James L Rushworth, Katherine S Montgomery, Benjamin Cao, Robert Brown, Nick J Dibb, Susan K Nilsson, John Chiefari, Matthew J Fuchter
ACS APPLIED BIO MATERIALS | AMER CHEMICAL SOC | Published : 2020
The functional group tolerance and simplicity of reversible addition fragmentation chain transfer (RAFT) polymerization enable its use in the preparation of a wide range of functional polymer architectures for a variety of applications, including drug delivery. Given the role of tumor-associated macrophages (TAMs) in cancer and their dependence on the tyrosine kinase receptor FMS (CSF-1R), the key aim of this work was to achieve effective delivery of an FMS inhibitor to cells using a polymer delivery system. Such a system has the potential to exploit biological features specific to macrophages and therefore provide enhanced selectivity. Building on our prior work, we have prepared RAFT polym..View full abstract
Awarded by EPSRC
Funding for this work was provided by the Commonwealth Scientific and Industrial Research Organization (CSIRO) and Imperial College London. M.J.F. would like to thank the EPSRC for an Established Career Fellowship (EP/R00188X/1).