Journal article

Using Metamodeling to Identify the Optimal Strategy for Colorectal Cancer Screening

Hendrik Koffijberg, Koen Degeling, Maarten J IJzerman, Veerle MH Coupe, Marjolein JE Greuter

VALUE IN HEALTH | ELSEVIER SCIENCE INC | Published : 2021

Abstract

OBJECTIVES: Metamodeling can address computational challenges within decision-analytic modeling studies evaluating many strategies. This article illustrates the value of metamodeling for evaluating colorectal cancer screening strategies while accounting for colonoscopy capacity constraints. METHODS: In a traditional approach, the best screening strategy was identified from a limited subset of strategies evaluated with the validated Adenoma and Serrated pathway to Colorectal CAncer model. In a metamodeling approach, metamodels were fitted to this limited subset to evaluate all potentially plausible strategies and determine the best overall screening strategy. Approaches were compared based on..

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