Journal article

Clinical thresholds for diagnosing iron deficiency: comparison of functional assessment of serum ferritin to population based centiles

Gorkem Sezgin, Paul Monagle, Tze Ping Loh, Vera Ignjatovic, Monsurul Hoq, Christopher Pearce, Adam McLeod, Johanna Westbrook, Ling Li, Andrew Georgiou

SCIENTIFIC REPORTS | NATURE RESEARCH | Published : 2020

Abstract

Low serum ferritin is diagnostic of iron deficiency, yet its published lower cut-off values are highly variable, particularly for pediatric populations. Lower cut-off values are commonly reported as 2.5th percentiles, and is based on the variation of ferritin values in the population. Our objective was to determine whether a functional approach based on iron deficient erythropoiesis could provide a better alternative. Utilizing 64,443 ferritin test results from pediatric electronic health records, we conducted various statistical techniques to derive 2.5th percentiles, and also derived functional reference limits through the association between ferritin and erythrocyte parameters: hemoglobin..

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Grants

Awarded by Quality Use of Pathology Program, Department of Health, Government of Australia


Funding Acknowledgements

This study was supported by funding from the Quality Use of Pathology Program, Department of Health, Government of Australia (4-2QFVW4M). The funder played no role in the design, conduct, or reporting of this study.