Journal article
Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson's Disease
MC Bakeberg, M Riley, M Byrnes, A Jefferson, S Ghosh, MK Horne, S McGregor, R Stell, S Walters, T Evans, K Roberts, FL Mastaglia, RS Anderton
Parkinson S Disease | HINDAWI LTD | Published : 2020
DOI: 10.1155/2020/8296203
Abstract
Background. Heightened impulsivity has been reported in a subset of people with Parkinson's disease (PwP) and is considered a risk factor for the development of impulse control disorders (ICDs). However, at present, there are no recognised biochemical markers of heightened impulsivity. Objectives. To determine if ceruloplasmin, a serum marker involved in the regulation of iron and copper homeostasis, is associated with trait impulsivity in PwP. Methods. The study measured serum ceruloplasmin and impulsivity using the Barratt Impulsiveness Scale (BIS-11) in an Australian cohort of 214 PwP. Multivariate general linear models (GLMs) were used to identify whether higher serum ceruloplasmin level..
View full abstractGrants
Funding Acknowledgements
The study was funded by grant/research support from the Federal Cooperative Research Centre for Mental Health, the Perron Institute for Neurological and Translational Science, and the University of Notre Dame Australia. This research was carried out while MCB was in receipt of a Richard Walter Gibbon Medical Research Scholarship and an Australian Government Research Training Program Scholarship at the University of Western Australia.