Prevalence of hypoxia and correlation with glycolytic metabolism and angiogenic biomarkers in metastatic colorectal carcinoma

ST Lee; V Muralidharan; N Tebbutt; P Wong; C Fang; Z Liu; H Gan; J Sachinidis; K Pathmaraj; C Christophi; AM Scott

Journal article

Prevalence of hypoxia and correlation with glycolytic metabolism and angiogenic biomarkers in metastatic colorectal carcinoma

ST Lee, V Muralidharan, N Tebbutt, P Wong, C Fang, Z Liu, H Gan, J Sachinidis, K Pathmaraj, C Christophi, AM Scott

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | SPRINGER | Published : 2021

DOI: 10.1007/s00259-020-05074-5

Abstract

Purpose: Hypoxia is associated with aggressive tumour behaviour and can influence response to systemic therapy and radiotherapy. The prevalence of hypoxia in metastatic colorectal cancer is poorly understood, and the relationship of hypoxia to patient outcomes has not been clearly established. The aims of the study were to evaluate hypoxia in metastatic colorectal cancer with [18F]Fluoromisonidazole ([18F]FMISO PET) and correlate these findings with glycolytic metabolism ([18F]FDG PET) and angiogenic blood biomarkers and patient outcomes. Methods: Patients with metastatic colorectal cancer received routine staging investigations and both [18F] FMISO PET and [18F] FDG PET scans. Correlative b..

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University of Melbourne Researchers

Vijayaragavan Muralidharan Author

Niall Tebbutt Author

Andrew Scott Author

Grants

Awarded by NHMRC

Funding Acknowledgements

Funding from the Cancer Council Victoria and University of Melbourne for Sze Ting Lee, NHMRC grants (No. 1084178 and 1092788), and Operational Infrastructure Support Program provided by the Victorian Government is acknowledged.