Journal article

Tranexamic acid in patients with intracerebral haemorrhage (STOP-AUST): a multicentre, randomised, placebo-controlled, phase 2 trial

Atte Meretoja, Nawaf Yassi, Teddy Y Wu, Leonid Churilov, Gerli Sibolt, Jiann-Shing Jeng, Timothy Kleinig, Neil J Spratt, Vincent Thijs, Tissa Wijeratne, Der-Yang Cho, Darshan Shah, Geoffrey C Cloud, Phan Thanh, Christopher Bladin, Andrew Moey, Richard I Aviv, Christen D Barras, Gagan Sharma, Chung Y Hsu Show all

The Lancet Neurology | ELSEVIER SCIENCE INC | Published : 2020

Abstract

BACKGROUND: Despite intracerebral haemorrhage causing 5% of deaths worldwide, few evidence-based therapeutic strategies other than stroke unit care exist. Tranexamic acid decreases haemorrhage in conditions such as acute trauma and menorrhoea. We aimed to assess whether tranexamic acid reduces intracerebral haemorrhage growth in patients with acute intracerebral haemorrhage. METHODS: We did a prospective, double-blind, randomised, placebo-controlled, investigator-led, phase 2 trial at 13 stroke centres in Australia, Finland, and Taiwan. Patients were eligible if they were aged 18 years or older, had an acute intracerebral haemorrhage fulfilling clinical criteria (eg, Glasgow Coma Scale score..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by National Health and Medical Research Council-National Heart Foundation Career Development-Future Leader Fellowship


Awarded by Canadian Institutes of Health Research


Funding Acknowledgements

The study was funded by the Australian National Health and Medical Research Council, grant number 1081718, and the Royal Melbourne Hospital Foundation. NS was supported by a Cofunded National Health and Medical Research Council-National Heart Foundation Career Development-Future Leader Fellowship GNT1110629/100827. RA receives support from Canadian Institutes of Health Research, operating grant 362185.