Whole Genome In-Silico Analysis of South African G1P Rotavirus Strains Before and After Vaccine Introduction Over A Period of 14 Years.
Peter N Mwangi, Milton T Mogotsi, Mapaseka L Seheri, M Jeffrey Mphahlele, Ina Peenze, Mathew D Esona, Benjamin Kumwenda, A Duncan Steele, Carl D Kirkwood, Valantine N Ndze, Francis E Dennis, Khuzwayo C Jere, Martin M Nyaga
Vaccines | Published : 2020
Rotavirus G1P strains account for more than half of the group A rotavirus (RVA) infections in children under five years of age, globally. A total of 103 stool samples previously characterized as G1P and collected seven years before and seven years after introducing the Rotarix® vaccine in South Africa were processed for whole-genome sequencing. All the strains analyzed had a Wa-like constellation (G1-P-I1-R1-C1-M1-A1-N1-T1-E1-H1). South African pre- and post-vaccine G1 strains were clustered in G1 lineage-I and II while the majority (84.2%) of the P strains were grouped in P lineage-III. Several amino acid sites across ten gene segments with the exception of VP7 were under pos..View full abstract