Journal article

Whole Genome In-Silico Analysis of South African G1P[8] Rotavirus Strains Before and After Vaccine Introduction Over A Period of 14 Years.

Peter N Mwangi, Milton T Mogotsi, Mapaseka L Seheri, M Jeffrey Mphahlele, Ina Peenze, Mathew D Esona, Benjamin Kumwenda, A Duncan Steele, Carl D Kirkwood, Valantine N Ndze, Francis E Dennis, Khuzwayo C Jere, Martin M Nyaga

Vaccines | Published : 2020

Abstract

Rotavirus G1P[8] strains account for more than half of the group A rotavirus (RVA) infections in children under five years of age, globally. A total of 103 stool samples previously characterized as G1P[8] and collected seven years before and seven years after introducing the Rotarix® vaccine in South Africa were processed for whole-genome sequencing. All the strains analyzed had a Wa-like constellation (G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1). South African pre- and post-vaccine G1 strains were clustered in G1 lineage-I and II while the majority (84.2%) of the P[8] strains were grouped in P[8] lineage-III. Several amino acid sites across ten gene segments with the exception of VP7 were under pos..

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Grants

Awarded by Bill and Melinda Gates Foundation


Awarded by South African Medical Research Council


Awarded by Poliomyelitis Research Foundation


Awarded by National Research Foundation - South Africa