Creating In Vitro Three-Dimensional Tumor Models: A Guide for the Biofabrication of a Primary Osteosarcoma Model
Thomas Chow, Ilycia Wutami, Enrico Lucarelli, Peter F Choong, Serena Duchi, Claudia Di Bella
Tissue Engineering Part B Reviews | MARY ANN LIEBERT, INC | Published : 2020
Osteosarcoma (OS) is a highly aggressive primary bone tumor. The mainstay for its treatment is multiagent chemotherapy and surgical resection, with a 50-70% 5-year survival rate. Despite the huge effort made by clinicians and researchers in the past 30 years, limited progress has been made to improve patient outcomes. As novel therapeutic approaches for OS become available, such as monoclonal antibodies, small molecules, and immunotherapies, the need for OS preclinical model development becomes equally pressing. Three-dimensional (3D) OS models represent an alternative system to study this tumor: In contrast to two-dimensional monolayers, 3D matrices can recapitulate key elements of the tumo..View full abstract
Awarded by NHMRC
This work was supported by St Vincent's Hospital ( Melbourne) Research Endowment Fund 2019_2020_Duchi. C.D.B. holds an NHMRC Early Leadership Investigator Grant for musculoskeletal bioengineering. P.F.C. holds an NHMRC Practitioner Fellowship (1154203).