When B cells break bad: development of pathogenic B cells in Sjögren's syndrome.
Joanne H Reed, Gwenny Matthea Verstappen, Maureen Rischmueller, Vanessa L Bryant
Clinical and Experimental Rheumatology | Published : 2020
Primary Sjögren's syndrome (pSS) is often considered a B cell-mediated disease, yet the precise role of B cells in the pathogenesis is not fully understood. This is exemplified by the failure of multiple clinical trials directed at B cell depletion or inhibition. To date, most prognostic markers for severe disease outcomes are autoantibodies, but the underlying mechanisms by which B cells drive diverse disease presentations in pSS likely extend beyond autoantibody production. Here we outline an expanded role of B cells in disease pathogenesis drawing on examples from animal models of SS, and from other autoimmune diseases that share similar clinical or immunological abnormalities. We focus o..View full abstract