Journal article

Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis

Fatemeh Saberi Hosnijeh, Delphine Casabonne, Alexandra Nieters, Marta Solans, Sabine Naudin, Pietro Ferrari, James D Mckay, Yolanda Benavente, Elisabete Weiderpass, Heinz Freisling, Gianluca Severi, Marie-Christine Boutron Ruault, Caroline Besson, Claudia Agnoli, Giovanna Masala, Carlotta Sacerdote, Rosario Tumino, Jose Maria Huerta, Pilar Amiano, Miguel Rodriguez-Barranco Show all

International Journal of Cancer | WILEY | Published : 2020

Abstract

To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric..

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Grants

Awarded by Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR), CERCA Programme/Generalitat de Catalunya


Awarded by Cancer Research UK


Awarded by TRANSCAN/Dutch Cancer Society


Awarded by German Federal Ministry of Education and Research


Awarded by Medical Research Council


Awarded by Spanish Ministry of Economy and Competitiveness - Carlos III Institute of Health - FEDER funds/European Regional Develpment Fund (ERDF) - a way to build Europe


Awarded by Statistics Netherlands (The Netherlands)


Awarded by Wellcome Trust


Funding Acknowledgements

Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR), CERCA Programme/Generalitat de Catalunya for institutional support, Grant/Award Number: 2017SGR1085; Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Cancer Research UK, Grant/Award Numbers: 14136 (to EPIC-Norfolk), C570/A11692, C570/A16491; Centro de Investigacion Biomedica en Red: Epidemiologia y Salud Publica (CIBERESP), (Spain); Danish Cancer Society (Denmark); TRANSCAN/Dutch Cancer Society, Grant/Award Number: 179; NOVEL consortium; Dutch Ministry of Public Health, Welfare and Sports (VWS); Dutch Prevention Funds; Dutch ZON (Zorg Onderzoek Nederland); European Commission (DG-SANCO); Federal Ministry of Education and Research (BMBF); German Cancer Aid; German Cancer Research Center (DKFZ); German Federal Ministry of Education and Research, Grant/Award Number: BMBF 01EO1303; German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal (Germany); Institut Gustave Roussy; Institut National de la Sante et de la Recherche Medicale (France); International Agency for Research on Cancer; Ligue Natinale Contre le Cancer; LK Research Funds; Medical Research Council, Grant/Award Numbers: 1000143 (to EPIC-Norfolk), MR/M012190/1 (to EPICOxford); Mutuelle Generale de l'Education Nationale; Netherlands Cancer Registry (NKR); Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway); Spanish Ministry of Economy and Competitiveness -Carlos III Institute of Health cofunded by FEDER funds/European Regional Develpment Fund (ERDF) -a way to build Europe, Grant/Award Numbers: PI13/00061 (to Granada), PI13/01162 (to EPIC-Murcia), PI17/01280, PI14/01219 (to Barcelona); Statistics Netherlands (The Netherlands), Grant/Award Number: Grant number: ERC2009-AdG 232997; Swedish Cancer Society; Swedish Research Council and County Councils of Skane and Vasterbotten (Sweden); the Hellenic Health Foundation (Greece); Wellcome Trust, Grant/Award Number: 205212/Z/16/Z; World Cancer Research Fund (WCRF)