Cep55 overexpression promotes genomic instability and tumorigenesis in mice.
Debottam Sinha, Purba Nag, Devathri Nanayakkara, Pascal HG Duijf, Andrew Burgess, Prahlad Raninga, Veronique AJ Smits, Amanda L Bain, Goutham Subramanian, Meaghan Wall, John W Finnie, Murugan Kalimutho, Kum Kum Khanna
Communications Biology | Published : 2020
High expression of centrosomal protein CEP55 has been correlated with clinico-pathological parameters across multiple human cancers. Despite significant in vitro studies and association of aberrantly overexpressed CEP55 with worse prognosis, its causal role in vivo tumorigenesis remains elusive. Here, using a ubiquitously overexpressing transgenic mouse model, we show that Cep55 overexpression causes spontaneous tumorigenesis and accelerates Trp53+/- induced tumours in vivo. At the cellular level, using mouse embryonic fibroblasts (MEFs), we demonstrate that Cep55 overexpression induces proliferation advantage by modulating multiple cellular signalling networks including the hyperactivation ..View full abstract