Determinants of Cardiovascular Risk in 7000 Youth With Type 1 Diabetes in the Australasian Diabetes Data Network
Jenny J Couper, Timothy W Jones, Melissa Chee, Helen L Barrett, Philip Bergman, Fergus Cameron, Maria E Craig, Peter Colman, Elizabeth E Davis, Kim C Donaghue, P Gerry Fegan, P Shane Hamblin, D Jane Holmes-Walker, Craig Jefferies, Stephanie Johnson, Meng Tuck Mok, Bruce R King, Richard Sinnott, Glenn Ward, Benjamin J Wheeler Show all
The Journal of Clinical Endocrinology & Metabolism | ENDOCRINE SOC | Published : 2021
CONTEXT: Cardiovascular disease occurs prematurely in type 1 diabetes. The additional risk of overweight is not well characterized. OBJECTIVE: The primary aim was to measure the impact of body mass index (BMI) in youth with type 1 diabetes on cardiovascular risk factors. The secondary aim was to identify other determinants of cardiovascular risk. DESIGN: Observational longitudinal study of 7061 youth with type 1 diabetes followed for median 7.3 (interquartile range [IQR] 4-11) years over 41 (IQR 29-56) visits until March 2019. SETTING: 15 tertiary care diabetes centers in the Australasian Diabetes Data Network.Participants were aged 2 to 25 years at baseline, with at least 2 measurements of ..View full abstract
This research was conducted as part of the Australasian Diabetes Data Network. We are grateful to JDRF Australia, the Australian Research Council, and to the children and young people with diabetes and their families who provided the data. We acknowledge the work of Dr Loren Bruns, Senior Software Developer, Melbourne eResearch Group, the University of Melbourne. This research was supported by JDRF Australia, the recipient of the Australian Research Council Special Research Initiative in Type 1 Juvenile Diabetes and the Channel 7 Research Foundation of South Australia.