Journal article

Towards defining the outer membrane proteome of Porphyromonas gingivalis

Paul D Veith, Dhana G Gorasia, Eric C Reynolds

MOLECULAR ORAL MICROBIOLOGY | WILEY | Published : 2020

Abstract

Porphyromonas gingivalis is a Gram-negative anaerobic pathogen found in subgingival plaque associated with progressive periodontitis. Proteins associated with the outer membrane (OM) of Gram-negative pathogens are particularly important for understanding virulence and for developing vaccines. The aim of this study was to establish a reliable list of outer membrane associated proteins (Omps) for this organism. Starting with a list of 99 experimentally determined Omps, several bioinformatics tools were used to predict a further 52 proteins, leading to a predicted OM proteome of 151 proteins. The tools used included databases of protein families, prediction of OM β-barrels and structural homolo..

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Grants

Awarded by Australian Government Department of Industry, Science and Innovation


Awarded by Australian Research Council


Funding Acknowledgements

Australian Government Department of Industry, Science and Innovation, Grant/Award Number: 20080108; Australian Research Council, Grant/Award Number: DP200100941