Journal article

Towards defining the outer membrane proteome of Porphyromonas gingivalis

Paul D Veith, Dhana G Gorasia, Eric C Reynolds



Porphyromonas gingivalis is a Gram-negative anaerobic pathogen found in subgingival plaque associated with progressive periodontitis. Proteins associated with the outer membrane (OM) of Gram-negative pathogens are particularly important for understanding virulence and for developing vaccines. The aim of this study was to establish a reliable list of outer membrane associated proteins (Omps) for this organism. Starting with a list of 99 experimentally determined Omps, several bioinformatics tools were used to predict a further 52 proteins, leading to a predicted OM proteome of 151 proteins. The tools used included databases of protein families, prediction of OM β-barrels and structural homolo..

View full abstract


Awarded by Australian Government Department of Industry, Science and Innovation

Awarded by Australian Research Council

Funding Acknowledgements

Australian Government Department of Industry, Science and Innovation, Grant/Award Number: 20080108; Australian Research Council, Grant/Award Number: DP200100941