Ebselen prevents cigarette smoke-induced gastrointestinal dysfunction in mice
Gayathri K Balasuriya, Mitra Mohsenipour, Kurt Brassington, Aleksandar Dobric, Simone N De Luca, Kevin Mou, Huei Jiunn Seow, Chalystha Yie Qin Lee, Madushani Herath, Stanley MH Chan, Ross Vlahos, Elisa L Hill-Yardin
Clinical Science | PORTLAND PRESS LTD | Published : 2020
Gastrointestinal (GI) dysfunction is a common comorbidity of chronic obstructive pulmonary disease (COPD) for which a major cause is cigarette smoking (CS). The underlying mechanisms and precise effects of CS on gut contractility, however, are not fully characterised. Therefore, the aim of the present study was to investigate whether CS impacts GI function and structure in a mouse model of CS-induced COPD. We also aimed to investigate GI function in the presence of ebselen, an antioxidant that has shown beneficial effects on lung inflammation resulting from CS exposure. Mice were exposed to CS for 2 or 6 months. GI structure was analysed by histology and immunofluorescence. After 2 months of..View full abstract
Awarded by Australian Research Council Future Fellowship
Awarded by National Health and Medical Research Council of Australia
E.L.H.-Y. received an Australian Research Council Future Fellowship [grant number FT160100126] and an RMIT Vice Chancellor's Senior Research Fellowship that supported G.K.B. and M.M. R.V. is funded through the National Health and Medical Research Council of Australia [grant numbers APP1120522 and APP1138915]. The Hu antibody was a gift from Dr V. Lennon, Mayo Clinic, U.S.A.