Journal article

Risk Factors for Delirium and Cognitive Decline Following Coronary Artery Bypass Grafting Surgery: A Systematic Review and Meta-Analysis

Danielle Greaves, Peter J Psaltis, Daniel HJ Davis, Tyler J Ross, Erica S Ghezzi, Amit Lampit, Ashleigh E Smith, Hannah AD Keage

Journal of the American Heart Association | WILEY | Published : 2020

Abstract

Background Coronary artery bypass grafting (CABG) is known to improve heart function and quality of life, while rates of surgery-related mortality are low. However, delirium and cognitive decline are common complications. We sought to identify preoperative, intraoperative, and postoperative risk or protective factors associated with delirium and cognitive decline (across time) in patients undergoing CABG. Methods and Results We conducted a systematic search of Medline, PsycINFO, EMBASE, and Cochrane (March 26, 2019) for peer-reviewed, English publications reporting post-CABG delirium or cognitive decline data, for at least one risk factor. Random-effects meta-analyses estimated pooled odds r..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council Boosting Dementia Research Leadership Fellowship


Awarded by National Heart Foundation of Australia Vanguard Grant


Awarded by National Heart Foundation of Australia Future Leader Fellowship


Awarded by National Health and Medical Research Council Career Development Fellowship


Awarded by Wellcome Trust Intermediate Clinical Fellowship


Awarded by National Health and Medical Research Council-Australian Research Council Dementia Research Development Fellowship


Awarded by National Health and Medical Research CouncilAustralian Research Council Dementia Research Development Fellowship


Funding Acknowledgements

D. Greaves is supported by the Australian Government Research Training Program Scholarship. Dr Keage is supported by a National Health and Medical Research Council Boosting Dementia Research Leadership Fellowship (GNT1135676) and the National Heart Foundation of Australia Vanguard Grant (101758-VG 2017). Dr Psaltis is supported by a National Heart Foundation of Australia Future Leader Fellowship (FLF100412) and a National Health and Medical Research Council Career Development Fellowship (CDF1161506). Dr Davis is supported by a Wellcome Trust Intermediate Clinical Fellowship (WT107467). Dr Lampit is supported by a National Health and Medical Research Council-Australian Research Council Dementia Research Development Fellowship (GNT1108520). Dr Smith is supported by a National Health and Medical Research CouncilAustralian Research Council Dementia Research Development Fellowship (GNT1097397). This project was supported by a National Heart Foundation of Australia Vanguard Grant (101758-VG 2017).