Rationale Design of pH-Responsive Core-Shell Nanoparticles: Polyoxometalate-Mediated Structural Reorganization
Y Gao, J Xu, C Zhang, H Venugopal, SS Kermaniyan, G Such, C Ritchie
ACS Applied Nano Materials | American Chemical Society | Published : 2020
Herein, we report the rational design of pH-responsive core-shell nanoparticles that incorporate a polyoxometalate (POM) cargo. Cobalt (III)-substituted borotungstate [BIIIW11O39CoIII]6- (POM) was selected due to its stability, low oxidizing power, and the ability to form kinetically inert coordinate bonds with the pyridyl functionality of the hydrophobic core polymer (CP) to yield (POM@CP). Dispersion of the POM-polymer composite in acetone and subsequent nanoprecipitation via the addition of the amphiphilic copolymer (SP) yield the core-shell nanoparticles (SP)(POM@CP). Large-scale structural rearrangement is observed in response to acidification; this is a significantly different response..View full abstract
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Awarded by Australian Research Council
All authors gratefully acknowledge financial contributions from their respective funding sources. C.R. - Australian Research Council Future Fellowship - FT180100610 and Monash University, G.S. - Australian Research Council Discovery Project DP180100844.