Journal article

Acute skeletal muscle wasting and dysfunction predict physical disability at hospital discharge in patients with critical illness

Kirby P Mayer, Melissa L Thompson Bastin, Ashley A Montgomery-Yates, Amy M Pastva, Esther E Dupont-Versteegden, Selina M Parry, Peter E Morris

Critical Care (UK) | BMC | Published : 2020


BACKGROUND: Patients surviving critical illness develop muscle weakness and impairments in physical function; however, the relationship between early skeletal muscle alterations and physical function at hospital discharge remains unclear. The primary purpose of this study was to determine whether changes in muscle size, strength and power assessed in the intensive care unit (ICU) predict physical function at hospital discharge. METHODS: Study design is a single-center, prospective, observational study in patients admitted to the medicine or cardiothoracic ICU with diagnosis of sepsis or acute respiratory failure. Rectus femoris (RF) and tibialis anterior (TA) muscle ultrasound images were ob..

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