In silicocharacterisation of stand-alone response regulators ofStreptococcus pyogenes
Sean J Buckley, Mark R Davies, David J McMillan
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2020
Bacterial "stand-alone" response regulators (RRs) are pivotal to the control of gene transcription in response to changing cytosolic and extracellular microenvironments during infection. The genome of group A Streptococcus (GAS) encodes more than 30 stand-alone RRs that orchestrate the expression of virulence factors involved in infecting multiple tissues, so causing an array of potentially lethal human diseases. Here, we analysed the molecular epidemiology and biological associations in the coding sequences (CDSs) and upstream intergenic regions (IGRs) of 35 stand-alone RRs from a collection of global GAS genomes. Of the 944 genomes analysed, 97% encoded 32 or more of the 35 tested RRs. The..View full abstract
SJB received funding for this work in the form of an Australian Government PhD scholarship, which was conducted at the University of the Sunshine Coast.