Association of early life and acute pollen exposure with lung function and exhaled nitric oxide (FeNO). A prospective study up to adolescence in the GINIplus and LISA cohort

Katrina A Lambert; Iana Markevych; Bo-Yi Yang; Carl-Peter Bauer; Dietrich Berdel; Andrea von Berg; Karl-Christian Bergmann; Caroline Lodge; Sibylle Koletzko; Luke A Prendergast; Tamara Schikowski; Holger Schulz; Matthias Werchan; Joachim Heinrich; Marie Standl; Bircan Erbas

Journal article

Association of early life and acute pollen exposure with lung function and exhaled nitric oxide (FeNO). A prospective study up to adolescence in the GINIplus and LISA cohort

Katrina A Lambert, Iana Markevych, Bo-Yi Yang, Carl-Peter Bauer, Dietrich Berdel, Andrea von Berg, Karl-Christian Bergmann, Caroline Lodge, Sibylle Koletzko, Luke A Prendergast, Tamara Schikowski, Holger Schulz, Matthias Werchan, Joachim Heinrich, Marie Standl, Bircan Erbas

SCIENCE OF THE TOTAL ENVIRONMENT | ELSEVIER | Published : 2021

DOI: 10.1016/j.scitotenv.2020.143006

Abstract

BACKGROUND: Pollen exposure has both acute and chronic detrimental effects on allergic asthma, but little is known about its wider effects on respiratory health. This is increasingly important knowledge as ambient pollen levels are changing with the changing global climate. OBJECTIVE: To assess associations of pollen exposure with lung function and fractional exhaled nitric oxide (FeNO) at age 15 in two prospective German birth cohorts, GINIplus and LISA. METHODS: Background city-specific pollen exposure was measured in infancy (during the first three months of life), and contemporary (on the day of and 7 days prior to lung function measurement). Greenness levels within circular buffers (100..

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University of Melbourne Researchers

Caroline Lodge Author Melbourne School of Population and Global Health

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Awarded by Federal Ministry for Environment (IUF Dusseldorf)

Funding Acknowledgements

GINIplusThe GINIplus study was mainly supported for the first 3 years of the Federal Ministry for Education, Science, Research and Technology (interventional arm) and Helmholtz Zentrum Munchen (former GSF) (observational arm). The 4 year, 6 year, 10 year and 15 year follow-up examinations of the GINIplus study were covered from the respective budgets of the 5 study centres (Helmholtz Zentrum Munich (former GSF), Research Institute at Marien-Hospital Wesel, LMU Munich, TU Munich and from 6 years onwards also from IUF - Leibniz Research Institute for Environmental Medicine at the University of Dusseldorf) and a grant from the Federal Ministry for Environment (IUF Dusseldorf, FKZ 20462296). Further, the 15 year follow-up examination of the GINIplus study was supported by the Commission of the European Communities, the 7th Framework Program: MeDALL project, and as well by the companies Mead Johnson and Nestle.LISAThe LISA study was mainly supported by grants from the Federal Ministry for Education, Science, Research and Technology and in addition from Helmholtz Zentrum Munchen (former GSF), Helmholtz Centre for Environmental Research -UFZ, Leipzig, Research Institute at Marien-Hospital Wesel, Pediatric Practice, Bad Honnef for the first 2 years. The 4 year, 6 year, 10 year and 15 year follow-up examinations of the LISA study were covered from the respective budgets of the involved partners (Helmholtz Zentrum Munich (former GSF), Helmholtz Centre for Environmental Research -UFZ, Leipzig, Research Institute at Marion Hospital Wesel, Pediatric Practice, Bad Hormel, IUF -Leibniz-Research Institute for Environmental Medicine at the University of Dusseldorf) and in addition by a grant from the Federal Ministry for Environment (IUF Dusseldorf, FKZ 20462296). Further, the 15 -year follow-up examination of the LISA study was supported by the Commission of the European Communities, the 7th Framework Program: MeDALL project.