Journal article

Cannabinoids Inhibited Pancreatic Cancer via P-21 Activated Kinase 1 Mediated Pathway

Yang Yang, Huynh Nhi, Chelsea Dumesny, Kai Wang, Hong He, Mehrdad Nikfarjam

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2020

Abstract

The anti-cancer effects of cannabinoids including CBD (Cannabidiol) and THC ((-)-trans-∆9-tetrahydrocannabinol) have been reported in the case of pancreatic cancer (PC). The connection of these cannabinoids to KRas oncogenes that mutate in more than 90% of PC, and their effects on PD-L1, a key target of immune checkpoint blockade, have not been thoroughly investigated. Using cell lines and mouse models of PC, the effects of CBD and THC on cancer growth, the interaction between PC cells and a stromal cell, namely pancreatic stellate cells (PSCs), and the mechanism(s) involved were determined by cell-based assays and mouse study in vivo. CBD and THC inhibited the proliferation of PC, PSC, and ..

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Grants

Awarded by Austin Medical Research Foundation


Awarded by Melbourne Medical School Department of Surgery Seeding Grants


Awarded by China Postdoctoral Council


Funding Acknowledgements

This work is supported by Austin Medical Research Foundation grants (AMRF, He-2019, Nikfarjam-2020), Melbourne Medical School Department of Surgery Seeding Grants (Nikfarjam-2020), Pancare Foundation (www.pancare.org.au) and Tour De Cure grants. Yang Yang is supported by China Postdoctoral Council (No. 20180028) and Pancare Foundation.