Journal article

Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells

Jack Feehan, Moustapha Kassem, Robert J Pignolo, Gustavo Duque

Journal of Bone and Mineral Research | WILEY | Published : 2021


Circulating osteogenic progenitor (COP) cells are a population of cells in the peripheral blood with the capacity for bone formation, as well as broader differentiation into mesoderm‐like cells in vitro. Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases. © 2020 American Society for Bone and Mineral Research..

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University of Melbourne Researchers


Awarded by NovoNordisk foundation

Funding Acknowledgements

This research was supported through an Australian Government Research Training Program (RTP) Scholarship and Stipend to JF; seed grants from the Australian Institute for Musculoskeletal Science (AIMSS) to JF and GD; and the Robert and Alene Kogod Professorship in Geriatric Medicine to RJP. MK received grants from the NovoNordisk foundation (NNF170C00029290 and NNF150C0016284).