Journal article

Positive-unlabelled learning of glycosylation sites in the human proteome

Fuyi Li, Yang Zhang, Anthony W Purcell, Geoffrey I Webb, Kuo-Chen Chou, Trevor Lithgow, Chen Li, Jiangning Song

BMC Bioinformatics | BMC | Published : 2019

Abstract

BACKGROUND: As an important type of post-translational modification (PTM), protein glycosylation plays a crucial role in protein stability and protein function. The abundance and ubiquity of protein glycosylation across three domains of life involving Eukarya, Bacteria and Archaea demonstrate its roles in regulating a variety of signalling and metabolic pathways. Mutations on and in the proximity of glycosylation sites are highly associated with human diseases. Accordingly, accurate prediction of glycosylation can complement laboratory-based methods and greatly benefit experimental efforts for characterization and understanding of functional roles of glycosylation. For this purpose, a number..

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University of Melbourne Researchers

Grants

Awarded by Australian Research Council (ARC)


Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by National Institute of Allergy and Infectious Diseases of the National Institutes of Health


Awarded by NHMRC


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This research was supported by grants from the Australian Research Council (ARC) (LP110200333 and DP120104460), the National Health and Medical Research Council of Australia (NHMRC) (4909809, 1127948 and 1144652), the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (R01 AI111965), and a Major Inter-Disciplinary Research (IDR) project awarded by Monash University. A.W.P. is currently supported by an NHMRC Principal Research Fellowship (1137739). C.L. is currently an NHMRC CJ Martin Early Career Research Fellow (1143366). T.L. is an ARC Australian Laureate Fellow (FL130100038). The funding body played any roles in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.