Journal article

iProt-Sub: a comprehensive package for accurately mapping and predicting protease-specific substrates and cleavage sites

Jiangning Song, Yanan Wang, Fuyi Li, Tatsuya Akutsu, Neil D Rawlings, Geoffrey I Webb, Kuo-Chen Chou

Briefings in Bioinformatics | OXFORD UNIV PRESS | Published : 2019

Abstract

Regulation of proteolysis plays a critical role in a myriad of important cellular processes. The key to better understanding the mechanisms that control this process is to identify the specific substrates that each protease targets. To address this, we have developed iProt-Sub, a powerful bioinformatics tool for the accurate prediction of protease-specific substrates and their cleavage sites. Importantly, iProt-Sub represents a significantly advanced version of its successful predecessor, PROSPER. It provides optimized cleavage site prediction models with better prediction performance and coverage for more species-specific proteases (4 major protease families and 38 different proteases). iPr..

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University of Melbourne Researchers

Grants

Awarded by Australian Research Council (ARC)


Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by National Institute of Allergy and Infectious Diseases of the National Institutes of Health


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This work was financially supported by grants from the Australian Research Council (ARC) (grant numbers LP110200333 and DP120104460), the National Health and Medical Research Council of Australia (NHMRC) (grant number 4909809), the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (grant number R01 AI111965) and a Major Inter-Disciplinary Research (IDR) project awarded by Monash University.