Journal article

Properties of genes encoding transfer RNAs as integration sites for genomic islands and prophages in Klebsiella pneumoniae

Camilo Berríos-Pastén, Rodolfo Acevedo, Patricio Arros, Macarena Varas, Kelly Wyres, Margaret Lam, Kathryn Holt, Rosalba Lagos, Andrés Marcoleta

Cold Spring Harbor Laboratory | Published : 2020


ABSTRACT The evolution of traits including antibiotic resistance, virulence, and increased fitness in Klebsiella pneumoniae and related species has been linked to the acquisition of mobile genetic elements through horizontal transfer. Among them, genomic islands (GIs) preferentially integrating at genes encoding tRNAs and the tmRNA (t(m)DNAs) would be significant in promoting chromosomal diversity. Here, we studied the whole set of t(m)DNAs present in 66 Klebsiella chromosomes, investigating their usage as integration sites and the properties of the integrated GIs. A total of 5,624 t(m)DNAs were classified based on their sequence conservation, genomic context, and prevalence. 161 different G..

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University of Melbourne Researchers

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