Journal article
MLC tracking for lung SABR is feasible, efficient and delivers high-precision target dose and lower normal tissue dose
J Booth, V Caillet, A Briggs, N Hardcastle, G Angelis, D Jayamanne, M Shepherd, A Podreka, K Szymura, DT Nguyen, P Poulsen, R O'Brien, B Harris, C Haddad, T Eade, P Keall
Radiotherapy and Oncology | ELSEVIER IRELAND LTD | Published : 2021
Abstract
Background and purpose: The purpose of this work is to present the clinical experience from the first-in-human trial of real-time tumor targeting via MLC tracking for stereotactic ablative body radiotherapy (SABR) of lung lesions. Methods and materials: Seventeen patients with stage 1 non-small cell lung cancer (NSCLC) or lung metastases were included in a study of electromagnetic transponder–guided MLC tracking for SABR (NCT02514512). Patients had electromagnetic transponders inserted near the tumor. An MLC tracking SABR plan was generated with planning target volume (PTV) expanded 5 mm from the end-exhale gross tumor volume (GTV). A clinically approved comparator plan was generated with PT..
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Awarded by Royal North Shore Hospital
Funding Acknowledgements
The authors acknowledge Varian Medical Systems and Royal North Shore Hospital No2 Trust for supporting this study.