Broad-spectrum treatment of bacterial biofilms using magneto-responsive liquid metal particles
Samuel Cheeseman, Aaron Elbourne, Rashad Kariuki, Aswin Ramarao, Ali Zavabeti, Nitu Syed, Andrew J Christofferson, Ki Yoon Kwon, Woojin Jung, Michael D Dickey, Kourosh Kalantar-Zadeh, Christopher F McConville, Russell J Crawford, Torben Daeneke, James Chapman, Vi Khanh Truong
Journal of Materials Chemistry B | ROYAL SOC CHEMISTRY | Published : 2020
The formation and proliferation of bacterial biofilms on surfaces, particularly those on biomedical devices, is a significant issue that results in substantial economic losses, presenting severe health risks to patients. Furthermore, heterogeneous biofilms consisting of different bacterial species can induce the increase in pathogenicity, and the resistance to antimicrobial agents due to the synergistic interactions between the different species. Heterogeneous bacterial biofilms are notoriously difficult to treat due to the presence of extracellular polymeric substances (EPS) and, in conjunction with the rapid rise of multi-drug resistant pathogens, this means that new solutions for anti-bio..View full abstract
Awarded by CASS Foundation Medicine/Science grant
Awarded by ARC
Awarded by Jack Brockhoff Foundation (JBF Grant)
The authors would like to thank both the Microscopy and Microanalysis Facility (RMMF) and the MicroNano Research Facility (MNRF) at RMIT University for the use of their facilities. V. K. T. and M. D. acknowledge the support from Fulbright Australian-American Fulbright Commission and NC State RISF. This research was supported by a CASS Foundation Medicine/Science grant (REF. 8485). T. D. acknowledges funding received from the ARC (DE190100100). A. E. is funded in part by funding from the Jack Brockhoff Foundation (JBF Grant number 4655-2019-AE). We thank Matthew Quinn from Agilent to provide the Cary 3500 UV-Vis spectrophotometer.