Superficial peritoneal endometriotic lesions are histologically diverse and rarely demonstrate menstrual cycle synchronicity with matched eutopic endometrium
EM Colgrave, S Bittinger, M Healey, UP Dior, PAW Rogers, JR Keast, JE Girling, SJ Holdsworth-Carson
Human Reproduction | OXFORD UNIV PRESS | Published : 2020
STUDY QUESTION: Do menstrual cycle-dependent changes occur in the histological appearance of superficial peritoneal endometriotic lesions, and are they equivalent to those observed in the eutopic endometrium? SUMMARY ANSWER: Only a small subset of superficial peritoneal endometriotic lesions exhibits some histological features in phase with menstrual cycle-related changes observed in eutopic endometrium. WHAT IS KNOWN ALREADY: Endometriotic lesions are frequently described as implants that follow menstrual cycle-related changes in morphology, as per the eutopic endometrium. This concept has been widely accepted despite the lack of conclusive published evidence. STUDY DESIGN, SIZE, DURATION: ..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
Research reported in this publication was supported in part by National Health and Medical Research Council (NHMRC) project grants GNT 1012245, GNT 1105321 and GNT 1026033 (P.A.W.R., J.E.G. and S.J.H.-C.).