Journal article

Long-term Survival with 18-Fluorodeoxyglucose Positron Emission Tomography-directed Therapy in Non-small Cell Lung Cancer with Synchronous Solitary Brain Metastasis

S Newman, N Bucknell, M Bressel, P Tran, BA Campbell, S David, N Haghighi, GG Hanna, D Kok, M MacManus, C Phillips, N Plumridge, M Shaw, A Wirth, G Wheeler, D Ball, S Siva

CLINICAL ONCOLOGY | ELSEVIER SCIENCE LONDON | Published : 2021

Abstract

AIMS: At diagnosis, <1% of patients with non-small cell lung cancer (NSCLC) have synchronous solitary brain metastasis (SSBM). In prior cohorts without 18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) staging, definitive treatment to intracranial and intrathoracic disease showed a 5-year overall survival (OS) of 11-21%. We investigated the long-term survival outcomes for patients with SSBM NSCLC, diagnosed in the FDG-PET/CT era and treated definitively with local therapies to both intracranial and intrathoracic sites of disease. MATERIALS AND METHODS: This retrospective study assessed patients staged with FDG-PET/CT who received definitive lung and SSBM tre..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

Shankar Siva was supported by a National Health and Medical Research Council fellowship grant APP1122347, as well as a Peter MacCallum Discovery Partner Fellowship.