Peripheral memory T-cell profile is modified in patients undergoing periodontal management
Nidhi Medara, Jason C Lenzo, Katrina A Walsh, James A Holden, Eric C Reynolds, Ivan B Darby, Neil M O'Brien-Simpson
JOURNAL OF CLINICAL PERIODONTOLOGY | WILEY | Published : 2020
AIMS: T-cells are known to have a role in periodontitis, however, the effect of periodontal therapy on peripheral memory T-cells is unclear. This study evaluated variation in peripheral memory T-cells and red complex bacteria in sub-gingival plaque in patients undergoing periodontal management. METHODS: Peripheral blood mononuclear cells and sub-gingival plaque were collected from 54 periodontitis patients at baseline, 3-, 6- and 12-months post-therapy and 40 healthy controls. Periodontitis patients were divided into treatment outcome (TxO) groups based on prevalence of sites with probing depth ≥5 mm as good (20%) at study conclusion. Naïve (TN -CCR7+ CD45RA+ ), central memory (TCM -CCR7+ CD..View full abstract
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Awarded by Australian National Health and Medical Research Council
Awarded by Australian Dental Research Foundation (ADRF)
This study was supported by grants from the Australian National Health and Medical Research Council (APP1029878) and the Australian Dental Research Foundation (ADRF, 120-2016).