Methylation marks of prenatal exposure to maternal smoking and risk of cancer in adulthood

Pierre-antoine Dugue; Allison Hodge; Ee Ming Wong; Eric Joo; Chol-Hee Jung; John Hopper; Dallas English; Graham Giles; Roger Milne; Melissa Southey

Journal article

Methylation marks of prenatal exposure to maternal smoking and risk of cancer in adulthood

Pierre-antoine Dugue, Allison Hodge, Ee Ming Wong, Eric Joo, Chol-Hee Jung, John Hopper, Dallas English, Graham Giles, Roger Milne, Melissa Southey

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | OXFORD UNIV PRESS | Published : 2021

DOI: 10.1093/ije/dyab168.173

Abstract

BACKGROUND: Prenatal exposure to maternal smoking is detrimental to child health but its association with risk of cancer has seldom been investigated. Maternal smoking induces widespread and long-lasting DNA methylation changes, which we study here for association with risk of cancer in adulthood. METHODS: Eight prospective case-control studies nested within the Melbourne Collaborative Cohort Study were used to assess associations between maternal-smoking-associated methylation marks in blood and risk of several cancers: breast (n = 406 cases), colorectal (n = 814), gastric (n = 166), kidney (n = 139), lung (n = 327), prostate (n = 847) and urothelial (n = 404) cancer and B-cell lymphoma (n ..

View full abstract

University of Melbourne Researchers

Chol-Hee Jung Author Medicine, Dentistry and Health Sciences

John Hopper Author Melbourne School of Population and Global Health

Dallas English Author Melbourne School of Population and Global Health

Eric Ji-Hoon Joo Author Clinical Pathology

Roger Milne Author Melbourne School of Population and Global Health

Related Projects (3)

Epidemiology of chronic disease, health interventions and DNA studies

nan

Methylation of DNA and colorectal cancer

Methylation of DNA involves a change to the chemical composition of DNA. It can affect the function of genes and normal methylation is essen..

A PROSPECTIVE STUDY OF THE INFLUENCE OF HEALTH - RELATED LIFESTYLE FACTORS ON DNA METHYLATION

It is known that DNA methylation can lead to disease. We aim to discover what causes DNA methylation to change. This could open the way for ..

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)

Awarded by Australian NHMRC

Awarded by NHMRC

Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) grant 1164455. MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian NHMRC grants 209057, 251553 and 504711 and by infrastructure provided by Cancer Council Victoria. The nested case-control methylation studies were supported by the NHMRC grants 1011618, 1026892, 1027505, 1050198, 1043616 and 1074383. M.C.S. is an NHMRC Senior Research Fellow (1061177).