Journal article

Methylation marks of prenatal exposure to maternal smoking and risk of cancer in adulthood

Pierre-antoine Dugue, Allison Hodge, Ee Ming Wong, Eric Joo, Chol-Hee Jung, John Hopper, Dallas English, Graham Giles, Roger Milne, Melissa Southey



BACKGROUND: Prenatal exposure to maternal smoking is detrimental to child health but its association with risk of cancer has seldom been investigated. Maternal smoking induces widespread and long-lasting DNA methylation changes, which we study here for association with risk of cancer in adulthood. METHODS: Eight prospective case-control studies nested within the Melbourne Collaborative Cohort Study were used to assess associations between maternal-smoking-associated methylation marks in blood and risk of several cancers: breast (n = 406 cases), colorectal (n = 814), gastric (n = 166), kidney (n = 139), lung (n = 327), prostate (n = 847) and urothelial (n = 404) cancer and B-cell lymphoma (n ..

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Awarded by Australian National Health and Medical Research Council (NHMRC)

Awarded by Australian NHMRC

Awarded by NHMRC

Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) grant 1164455. MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian NHMRC grants 209057, 251553 and 504711 and by infrastructure provided by Cancer Council Victoria. The nested case-control methylation studies were supported by the NHMRC grants 1011618, 1026892, 1027505, 1050198, 1043616 and 1074383. M.C.S. is an NHMRC Senior Research Fellow (1061177).