Journal article

Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19

Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul V Licciardi, Sohinee Sarkar, Kevin J Selva, Anh Ha Do Lien, Celeste Donato, Zheng Quan Toh, Rachel Higgins, Carolien Van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Katie L Flanagan, Kelly B Arnold, Francesca L Mordant, Kim Mulholland, Julie Bines, Kate Dohle Show all



Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptomatic infections, but the underlying immunological differences remain unclear. Here, we describe clinical features, virology, longitudinal cellular, and cytokine immune profile, SARS-CoV-2-specific serology and salivary antibody responses in a family of two parents with PCR-confirmed symptomatic SARS-CoV-2 infection and their three children, who tested repeatedly SARS-CoV-2 PCR negative. Cellular immune profiles and cytokine responses of all children are similar to their parents at all timepoints. All family members have salivary anti-SARS-CoV-2 antibodies detected..

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Awarded by NHMRC Career Development Fellowship

Awarded by NHMRC Leadership Investigator Grant

Awarded by NHMRC Investigator Grant

Awarded by NHMRC Program Grant

Awarded by Research Grants Council of the Hong Kong Special Administrative Region, China

Awarded by NHMRC Senior Research Fellowship

Awarded by European Union

Awarded by NHMRC

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

We acknowledge Dale Godfrey and Adam Wheatley for generously sharing recombinant proteins related to SARS-CoV-2. We also acknowledge Bruce Wines and Mark Hogarth for generously sharing their recombinant Fc-dimers. M.R.N. is supported by a Melbourne Children's LifeCourse Fellowship, P.V.L. is supported by NHMRC Career Development Fellowship (#1146198), P.S. is supported by a DHB Foundation Fellowship. This work was supported by Jack Ma Foundation to K.K., A.W.C., and K.S., the a2 Milk Foundation to KS, the Clifford Craig Foundation to KLF and KK, NHMRC Leadership Investigator Grant to K.K. (1173871), NHMRC Investigator Grant to K.S. (1177174), NHMRC Program Grant to K.K. (1071916), Research Grants Council of the Hong Kong Special Administrative Region, China (#T11-712/19-N) to K.K. A.W.C. is supported by a NHMRC Career Development Fellowship (#1140509), KK by NHMRC Senior Research Fellowship (1102792), C.E.S. has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skodowska-Curie grant agreement (#792532), and DPB by NHMRC Investigator Grant (#1175744). This work is supported by Victorian Government's Medical Research Operational Infrastructure Support Program. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health.