Journal article

Necroptotic movers and shakers: cell types, inflammatory drivers and diseases

Ashley Weir, Sebastian Hughes, Maryam Rashidi, Joanne M Hildebrand, James E Vince

CURRENT OPINION IN IMMUNOLOGY | CURRENT BIOLOGY LTD | Published : 2021

Abstract

The necroptotic cell death pathway has received significant attention for its ability to trigger inflammatory responses and its potential involvement in related conditions. Recent insights into the essential membrane damaging necroptotic pseudokinase effector, Mixed lineage kinase domain like (MLKL), have revealed a number of diverse MLKL functions that contribute to the inflammatory nature of necroptosis. Here we review distinct MLKL signalling roles and document the immunogenic molecules released by necroptosis. We discuss specific in vivo MLKL-driven responses, the activation of inflammasome complexes and innate lymphoid cells, which have been documented to drive disease. Finally, we list..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Health and Medical Research Council


Awarded by operational infrastructure grants through the Australian Government Independent Research Institute Infrastructure Support Scheme


Funding Acknowledgements

We apologise to authors whose work we were unable to discuss or cite due to space constraints. JEV is supported by National Health and Medical Research Council of Australia project grants (1145788 and 1101405), an ideas grant (1183070) and fellowship (1141466). M.R. is supported by a Mathison Centenary fellowship, The University of Melbourne. J.M.H is supported by a National Health and Medical Research Council fellowship (1142669). This work was also supported by operational infrastructure grants through the Australian Government Independent Research Institute Infrastructure Support Scheme (9000587) and the Victorian State Government Operational Infrastructure Support, Australia.