Journal article

In vivo microstructural heterogeneity of white matter lesions in healthy elderly and Alzheimer's disease participants using tissue compositional analysis of diffusion MRI data

Remika Mito, Thijs Dhollander, Ying Xia, David Raffelt, Olivier Salvado, Leonid Churilov, Christopher C Rowe, Amy Brodtmann, Victor L Villemagne, Alan Connelly

NeuroImage Clinical | ELSEVIER SCI LTD | Published : 2020


White matter hyperintensities (WMH) are regions of high signal intensity typically identified on fluid attenuated inversion recovery (FLAIR). Although commonly observed in elderly individuals, they are more prevalent in Alzheimer's disease (AD) patients. Given that WMH appear relatively homogeneous on FLAIR, they are commonly partitioned into location- or distance-based classes when investigating their relevance to disease. Since pathology indicates that such lesions are often heterogeneous, probing their microstructure in vivo may provide greater insight than relying on such arbitrary classification schemes. In this study, we investigated WMH in vivo using an advanced diffusion MRI method k..

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Awarded by NHMRC

Funding Acknowledgements

We are grateful to the National Health and Medical Research Council (NHMRC) of Australia and the Victorian Government's Operational Infrastructure Support Program for their funding support. VV is supported by an NHMRC Research Fellowship (1046571). RM is supported by a Melbourne International Research Scholarship from the University of Melbourne and Yulgibar Alzheimer's Research Program Award.