Journal article

Noise and the molecular processes underlying cell fate decision-making

Anissa Guillemin, Michael PH Stumpf

Physical Biology | IOP PUBLISHING LTD | Published : 2021

Abstract

Cell fate decision-making events involve the interplay of many molecular processes, ranging from signal transduction to genetic regulation, as well as a set of molecular and physiological feedback loops. Each aspect offers a rich field of investigation in its own right, but to understand the whole process, even in simple terms, we need to consider them together. Here we attempt to characterise this process by focussing on the roles of noise during cell fate decisions. We use a range of recent results to develop a view of the sequence of events by which a cell progresses from a pluripotent or multipotent to a differentiated state: chromatin organisation, transcription factor stoichiometry, an..

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University of Melbourne Researchers

Grants

Funding Acknowledgements

We would like to thank the members of the Theoretical Systems Biology Group for many fruitful discussions of cell-fate decision making processes and especially Megan Coomer for her proofreading expertise. AG and MPHS gratefully acknowledge funding from the Driving Research Momentum fund.