Journal article

Depression mediates the relationship between fatigue and mental health-related quality of life in multiple sclerosis

Alexander Fidao, Alysha De Livera, Nupur Nag, Sandra Neate, George A Jelinek, Steve Simpson-Yap

MULTIPLE SCLEROSIS AND RELATED DISORDERS | ELSEVIER SCI LTD | Published : 2021

Abstract

BACKGROUND: Fatigue is among the most prevalent symptoms for people with multiple sclerosis (pwMS) and is significantly detrimental to mental health-related (mental) quality of life (QoL). We examined the role of depression and physical activity as mediators in the fatigue-QoL relationship in pwMS. METHODS: Using baseline cross-sectional data from an international cohort of 2,104 pwMS, characteristics of fatigue and mental QoL, measured by Fatigue Severity Scale and MSQOL-54 respectively, were assessed using linear and log-binomial regression. Structural Equation Models (SEM) were used to explore the mediating roles of depression and physical activity between fatigue and mental QoL. RESULTS:..

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